Well,I was playing Call of Duty 4 again,and them I re-played the Aftermath level,and go really sad knowing the Paul had a wife and kids,in the end he dies by that explosion and he hears his daughter voice before die .That really touch me. Now tell me a moment in that touch you,it can be from the history or something directly related.

Jill Valentine's headstone. The moment I first saw that name on it, I literally burst into tears.

Bernard wrote:

Well,I was playing Call of Duty 4 again,and them I re-played the Aftermath level,and go really sad knowing the Paul had a wife and kids,in the end he dies by that explosion and he hears his daughter voice before die

So that's what that haunting laughter was? Jackson's kid in his head? I always thought it was some kind of quiet "war is evil" message (of which I already get enough of in MGS).

I did kinda feel upset, though, when I saw the Cobra pilot dead outside the wreckage of the Sea Knight in that scene. She was kind of hot...

There are plenty, like Ada's supposed death in RE2, the scene where Billy sees the skeletons that Marcus had tested on, the scene where Alexia awakes after her 15 years of slumber, also in Sons Of Liberty when Emma Emmerich dies, and the Sonic Adventure opening is just epic.

Final level of CoD 4 was saddest if you ask me... You popped some heads while both you and sgt. were seriously injured... But Sarge gave his life... At least he done something for his country

In Resident Evil 3 when Mikhail dies (and you can't save him)
It makes me sad

Another one that really got to me was the end of MGS4.

Spoiler:
	When I watched Snake putting the gun in his mouth and cocking back the hammer, the thought of him dying like that just killed me. Then the screen cuts to black and we hear the gunshot.

Just like with Jill's headstone, I burst into tears right there because it was the last thing I ever wanted to see from a character I'd loved for so long.