Yes its possible, just depending on what RE engine your using.
If you want to use the RE1 engine then the room data from 2 and 3 wont work.
You could reskin the room data in RE1 to look like RE2 but that would be pointless.
If you want to mod your best bet is to use the RE2 engine.

Although the fact you are asking such a simple question means you dont have knowledge in modding.
If not I would recomned you start learning the very basic and everything about it.
A good knowledge of photoshop and having artistic creativity is a must also.
There is Resident evil modding forums you can visit that will give you information and tools you need.
Also make sure you have a good understanding of 3d software like cinema 4d, 3ds max or milkshape (think thats free)