Guys I dont know what the problem is, I dont really see how he changed. I mean in CV he was going around smacking bitches and using lazer eyes and jumping over walls and doing like black flip kicks and going all ninja and shit. It was just portrayed better on 360/PS3.

cant say that im that fond of the Re5 wesker. i prefer the ruthless and two faced wesker of Re1.

@Charlie, ya I really liked the RE1 Wesker as well.

If you think about it, there's a thread in Wesker's progression. He started out as very cruel and ruthless, but not necessarily a megalomaniac. I think for him, Umbrella was the ultimate source of power that had to be dominant over global affairs, but not necessarily rule the world directly. Umbrella however went under, and Wesker thus had to reformulate his theories; the company that had literally given birth to him was no more powerful than Enron, just nastier, and thus could be discarded. I also think after RE1, his failure with the tyrant and his growing obsession with Chris made him feel the need to have more direct control over his plans, and not mediate them through others.

After potential rivals like Alexia were destroyed, I think that his ego and sense of power grew even more, and he increasingly saw anyone who was not of direct use to him as redundant and utterly disposable. This is just a theory of mine, but I think that Wesker did not have Ada directly go after Leon because he knew that Saddler was a serious threat to his own power and that Leon was probably the best bet to have him eliminated. Get around to the events at the Spencer Estate and then RE5, and Wesker had completely adopted Spencer's "god" ideas, brought on by the events directly surrounding his murder of Spencer, and had come to the conclusion that absolutely anyone who was not like him did not deserve to live. If you think about it, it makes sense; all his attempts to delegate power through lesser being had failed, thus they all had to die and only he himself could rule. Also, he may have been experiencing some problems due to possible experimentation on himself; we heard nothing about him having to take shots before RE5. Granted, we don't see much of him outside direct gameplay, but it is something to think about. If his body was starting to break down, his mental state might have been deteriorating, leading him to believe that complete genocide was what was necessary to eliminate all who had or who might ever oppose him. This might also explain the eyes, as before he might have been able to control their color, but as he broke down, they became permanently yellow.

I'm with spike here. Old Wesker ftw. Btw, Sephiroth will always be the coolest game villain ever.